When you're faced with deep tissue trauma—whether from injury, disease, or surgery—you need more than a simple patch. SIS+ is a porcine-derived small intestine submucosa enhanced with our unique ion therapy that doesn't just cover a defect; it actively guides your patient's body to rebuild functional tissue.

Unlike synthetic materials that can lead to encapsulation and chronic inflammation, SIS+ provides a biocompatible scaffold that your patient's cells recognize and remodel into their own healthy tissue.

How SIS+ Works: The Science of Healing

What It Is: SIS+ is processed to maintain the three-dimensional extracellular matrix structure while removing cellular components. This leaves behind structural proteins (collagen, elastin), proteoglycans, and GAG compounds—the natural framework for tissue repair.

Our Unique Ion Enhancement: The proprietary ion therapy process enhances SIS+'s natural angiogenic promoters, accelerating the healing cascade and reducing infection potential.

The Healing Process:

1. Immediate Support (Days 1-7): The matrix provides mechanical strength while preventing bacterial invasion through its anti-microbial properties

2. Active Remodeling (Weeks 2-6): Host cells migrate into the scaffold, laying down organized collagen as the SIS+ gradually resorbs

3. Functional Restoration (Weeks 6-12): New tissue develops with appropriate strength, vascularization, and minimal scar formation

Why This Matters: The gradual replacement of SIS+ with native tissue means you get permanent repair without permanent foreign material—reducing long-term complications like chronic inflammation, mesh erosion, or rejection.