SIS+ Tissue Patch
Advanced Biological Repair Through Natural Remodeling
Remodeling, Not Replacement
When you're faced with deep tissue trauma—whether from injury, disease, or surgery—you need more than a simple patch. SIS+ is a porcine-derived small intestine submucosa enhanced with our unique ion therapy that doesn't just cover a defect; it actively guides your patient's body to rebuild functional tissue.
Unlike synthetic materials that can lead to encapsulation and chronic inflammation, SIS+ provides a biocompatible scaffold that your patient's cells recognize and remodel into their own healthy tissue.
How SIS+ Works: The Science of Healing
What It Is: SIS+ is processed to maintain the three-dimensional extracellular matrix structure while removing cellular components. This leaves behind structural proteins (collagen, elastin), proteoglycans, and GAG compounds—the natural framework for tissue repair.
Our Unique Ion Enhancement: The proprietary ion therapy process enhances SIS+'s natural angiogenic promoters, accelerating the healing cascade and reducing infection potential.
The Healing Process:
Immediate Support (Days 1-7): The matrix provides mechanical strength while preventing bacterial invasion through its anti-microbial properties
Active Remodeling (Weeks 2-6): Host cells migrate into the scaffold, laying down organized collagen as the SIS+ gradually resorbs
Functional Restoration (Weeks 6-12): New tissue develops with appropriate strength, vascularization, and minimal scar formation
Why This Matters: The gradual replacement of SIS+ with native tissue means you get permanent repair without permanent foreign material—reducing long-term complications like chronic inflammation, mesh erosion, or rejection.
Your Partner in Tissue Transformation
Here's what sets SIS+ apart: while other products just cover wounds, SIS+ transforms them. This isn't about slapping a patch on tissue and hoping for the best—it's about giving damaged tissue the biological scaffolding it needs to rebuild itself stronger.
Our porcine-derived small intestine submucosa comes enhanced with ionic wash technology that does something remarkable: it doesn't just heal tissue, it helps regenerate it. Think of it as the difference between putting a band-aid on a problem versus actually solving it.
What Makes SIS+ Different
This is where it gets exciting. SIS+ doesn't work instead of your patient's natural healing—it works with it:
True biological integration: The matrix absorbs as your patient's own tissue takes over
Ionic advantage: Our unique wash process drives faster healing and keeps infections at bay
Surgical confidence: High suture retention means it stays where you put it
Flexible strength: Supports tissue without restricting natural movement
Active healing: Mitogenic properties actually stimulate tissue regeneration
When to Reach for SIS+
Body Wall & Internal:
Hernia repairs & abdominal wall reconstruction
Thoracic defects
Oral nasal fistulas
Dura-cap repair/replacement
Specialized Applications:
Corneal defects (we have ocular-specific sizes)
Any surgical scenario where you need tissue support that becomes the tissue
For detailed clinical studies, and application techniques, visit the SIS+ Tissue Patches page.
Support and promotion of wound healing and tissue remodeling by providing a biocompatible, absorbable tissue repair matrix
Angiogenic promoters, including a unique combination of ions which promote rapid healing and a reduced infection potential
Excellent physical properties, including high suture retention and bursting strength
Encouragement of rapid tissue ingrowth
Mitogenic
Anti-microbial
Features & Benefits
Indications for use of SIS+™ tissue patches include:
Hernia repairs
Abdominal wall reconstruction
Thoracic defects
Oral nasal fistulas
Dura-cap repair/replacement
Ocular patches are suitable for:
Deep melting ulcers
Corneal laceration
Full-thickness corneal defects
Corneal ulcers or other tissue repairs
SIS+™ is available in a variety of sizes and thicknesses to meet your needs.
Indications for Use
Additional Resources
Our Distributors:
